Cefpodoxime

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• What Is Cefpodoxime and How Does It Work?
• What Are Side Effects Associated with Using Cefpodoxime?
• What Other Drugs Interact with Cefpodoxime?
• What Are Warnings and Precautions for Cefpodoxime?

Brand Name: Vantin

Generic Name: Cefpodoxime

Drug Class: Cephalosporins, 3rd Generation

What Is Cefpodoxime and How Does It Work?

Cefpodoxime

Cefpodoxime is an oral, third-generation cephalosporin antibiotic. It is active against most Gram-positive and Gram-negative organisms. Notable exceptions include Pseudomonas aeruginosa, Enterococcus, and Bacteroides fragilis.

 

Cefpodoxime is a prescription drug used to treat a wide variety of bacterial infections. Cefpodoxime is known as a cephalosporin antibiotic. It works by stopping the growth of bacteria.
Cefpodoxime treats only bacterial infections. It will not work for viral infections (common cold, flu). Unnecessary use or misuse of any antibiotic can lead to its decreased effectiveness.
Cefpodoxime is available under the following different brand names: Vantin.
Dosages of Cefpodoxime:
Adult and Pediatric Dosages:
Oral suspension

• 50 mg/5 ml
• 100 mg/5 ml

Tablet

• 100 mg
• 200 mg

Dosage Considerations – Should be Given as Follows:
Acute Bronchitis and Acute Exacerbations of Chronic Bronchitis

• 200 mg orally every 12 hours for 10 days

Acute Community-Acquired Pneumonia

• 200 mg orally every 12 hours for 14 days

Acute Maxillary Sinusitis
Adult

• 200 mg orally every 12 hours for 10 days

Pediatric

• Infants under 2 months: safety and efficacy not established
• Infants 2 months – Children 12 years: 5 mg/kg orally every 12 hours for 10 days; individual doses not to exceed 200 mg
• Children over 12 years: 200 mg orally every 12 hours for 10 days

Pharyngitis/Tonsillitis
Adult

• 100 mg orally every 12 hours for 5-10 days

Pediatric

• Infants under 2 months: safety and efficacy not established
• Infants 2 months – Children 12 years: 5 mg/kg orally every 12 hours for 5-10 days; individual doses not to exceed 100 mg
• Children over 12 years: 100 mg orally every 12 hours for 5-10 days

Skin/Skin Structure Infections

• 400 mg orally every 12 hours for 7-14 days

Gonorrhea

• Uncomplicated gonorrhea in men and women; rectal gonococcal infections in women
• 200 mg orally once

Uncomplicated Urinary Tract Infections

• 100 mg orally every 12 hours for 7-14 days

Acute Otitis Media
Pediatric

• Infants under 2 months: safety and efficacy not established
• Infants 2 months – Children 12 years: 5 mg/kg orally every 12 hours for 5 days; individual doses not to exceed 200 mg
• Children over 12 years: 200 mg orally every 12 hours for 5 days

Dosing Modifications
Renal impairment

• Creatinine clearance under 30 ml/min: give every 24 hours
• Hemodialysis: give 3 times weekly after dialysis

Hepatic impairment

• Dosage adjustment not necessary

Dosing Considerations
Susceptible organisms

• Bacteroides fragilis, Clostridium perfringens, Escherichia coli, Haemophilus influenzae, Klebsiella spp, Moraxella catarrhalis, Neisseria gonorrhoeae, Proteus mirabilis, staphylococci, group A beta-hemolytic Streptococci, Streptococcus pyogenes

What Are Side Effects Associated with Using Cefpodoxime?

Common side effects of cefpodoxime include:

• abdominal pain
• anxiety
• back pain
• bloating
• body aches
• chest tightness
• chills
• confusion or weakness
• constipation
• cough
• dark colored urine
• diaper rash in an infant taking liquid cefpodoxime
• diarrhea
• dizziness
• dry mouth
• fast or pounding heartbeats
• feeling like you might pass out
• feeling restless or hyperactive
• shortness of breath (even with mild exertion)
• fever
• flu symptoms
• fungal skin rash
• gas
• headache
• headache with severe blistering, peeling or red skin rash
• increased thirst
• loss of appetite
• mild itching
• muscle pain
• nausea
• nervousness
• numbness or tingly feeling, warmth or redness under the skin
• pale or yellowed skin
• rapid weight gain
• rash
• seizures (convulsions)
• skin rash
• sore throat
• spinning sensation (vertigo)
• stiff or tight muscles
• stomach pain
• strange dreams, nightmares
• stuffy nose
• swelling
• tired feeling
• trouble breathing
• unusual bleeding or bruising
• unusual or unpleasant taste in your mouth
• urinating less than usual or not all
• vaginal itching or discharge
• vomiting
• watery or bloody diarrhea
• wheezing
• white patches or sores inside your mouth or on your lips
• yellowing of the skin or eyes (jaundice)

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.
https://www.rxlist.com/consumer_cefpodoxime_vantin/drugs-condition.htm