Hypertension-new drug-S-amlodipine
S-Amlodipine
2.5 mg
new drug for mild to moderate hypertension
Multicentric, clinical trial of S-Amlodipine 2.5 mg versus
Amlodipine 5 mg in the treatment of mild to moderate hypertension--a
randomized, double-blind clinical trial.
uses-treatment
of mild to moderate hypertension
There was no
statistically significant change in the levels of serum creatinine, SGOT, SGPT,
HDL, LDL, triglyceride and total cholesterol in patients receiving
Amlodipine 5 mg. The
reduction in total cholesterol as well as triglyceride level in the
S-Amlodipine 2.5 mg treatment group was found to be greater but it failed to show
any statistically significant difference.
CONCLUSION:
S-Amlodipine
2.5 mg is found to be equivalent in its efficacy and tolerability when
compared to Amlodipine 5 mg in the treatment of mild to moderate hypertension.
(S)-amlodipine treatment was associated with significantly less edema than racemic
amlodipine
Ref;
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